Acute and chronic pain remain significant health problems despite tremendous progress in the understanding of their basic mechanisms. Studies conducted using intact animals allow the examination of the multidimensional nature of pain. Aragen scientists have developed various animal models to evaluate the efficacy of novel drug candidates against inflammatory, neuropathic and cancer pain.

  • Neuropathic Pain Models
    • Effect of tramadol on CCI (chronic constructive injury)-induced neuropathic pain in rats
    • Effect of gabapentin on SNL (spinal nerve ligation)-induced neuropathic pain in rats
    • Paclitaxel-induced polyneuropathic pain in rats
    • Streptozotocin-induced polyneuropathic pain in rats
  • Post-operative Pain Models
    • Brennan model of post-incisional pain in rats and mice
  • Inflammatory Pain Models
    • Complete Freund’s Adjuvant (CFA)-induced pain in rats
    • λ-carrageenan-induced pain in rats
    • MIA-induced osteoarthritis in rats
    • Formalin-induced Pain in mice