Chemistry

Harnessing Agility and Innovation to Unleash the Potential of Discovery Chemistry at Aragen Life Sciences

At Aragen, we are a Contract Research, Development, and Manufacturing Organization (CRDMO) with over 25 years of expertise in providing innovative chemistry solutions. We combine frontier areas of chemistry with cutting-edge digital and AI technologies to accelerate drug discovery and development. Our team of over 2,500+ scientists and 300+ PhDs work in the state-of-the-art laboratories, solving complex synthetic challenges and identifying the most promising molecules for preclinical candidate nomination and development studies that can translate into the clinic.

• Our chemistry capabilities span:
  PROTACs chemistry, lipids, photo-redox chemistry, macrocycles, peptides, nucleic acid chemistry, ADCs, oligonucleotides, carbohydrates, organometallics and deuterated compounds.
• Advanced technology platforms: Parallel synthesis, direct to biology (D2B), high throughput experimentations (HTE), catalyst screening, electrochemistry, photo- redox, flow technology, and late-stage functionalization (LSF).

Our team of seasoned analytical scientists provides expert support in complex purification processes, final QC, and comprehensive structure elucidation for novel New Chemical Entities (NCEs). Our analytical and purification infrastructure includes advanced SFC capacity for chiral purification, ELSD/CAD techniques for purification and analysis of non-chromophoric compounds, and VCD analysis for accurate determination of absolute chirality.

We use proprietary and client-integrated electronic laboratory notebooks that are compliant with 21 CFR Part 11 requirements.

Our discovery chemistry platform is supported by experienced scientific talent, integrated project management practices and digital tools that help deliver chemistry solutions with speed, quality and consistency. As a full-service CRDMO, we offer flexible business models (FTE or FFS) and a customer-centric, no-conflict approach. This allows us to customize the size and composition of our teams, ensuring your project needs are met with faster cycle times. We ensure seamless transfer of compounds in assay plates or solids from our robotic compounds management to biology for running biological assays.

Aragen’s computational chemistry team brings deep expertise in informatics and AI/ML- driven approaches to accelerate drug design and development. Our capabilities span both structure-based and ligand-based drug design, supported by customized tools from Schrodinger and Cresset. By leveraging advanced data analytics platforms such as SARvision, DataWarrior, and other tailored solutions, we enhance the understanding of structure-activity relationships (SAR), enabling faster candidate identification and more efficient development cycles. Additionally, Aragen has developed its proprietary digital drug discovery platform,  InCoRe, which ensures seamless data integration and workflow continuity across the Design-Make-Test-Analyze (DMTA) cycle.