Immunology &

Inflammation is an early event that is the underlying cause of most diseases, including cancer. The inflammatory condition is associated with an activated immune system, including activated immune cells and biomolecules. Inflammatory models of diseases are therefore critical to the understanding of disease etiology across colitis, psoriasis, multiple sclerosis, arthritis and fibrosis. 

At Aragen, we employ animal models that show tissue-specific inflammation and utilize a variety of approaches, to evaluate novel treatments. Our preclinical research in immunology and inflammation focuses on arthritis and autoimmunity. Aragen scientists have expertise in preclinical investigations of the joints and lung functions in vivo, including bronchoalveolar lavage, cytology, immunohistochemistry, and analysis of biochemical, immunological and molecular parameters. Strong collaborations with various academic, governmental and industrial laboratories have enabled the development of several experimental models of immunology and inflammatory diseases.

  • Inflammatory Fibrosis
    • Bleomycin-induced idiopathic pulmonary fibrosis (IPF) in mouse and rats
    • Carbon tetrachloride (CCl4)-induced liver fibrosis
  • Colon Inflammation
    • Dextran sodium sulphate (DSS)-induced colitis model
  • Dermal Inflammation
    • Imiquimod-induced psoriasis in mice
    • IL-23-induced psoriasis in mice
    • Oxazolone-induced ear/skin inflammation in mice
  • Multiple Sclerosis
    • MOG 35-55-induced experimental autoimmune encephalitis (EAE) in mice
  • Inflammatory Arthritis
    • Collagen-induced arthritis in DBA1J mice
  • Arthritis
    • Collagen-induced arthritis: DBA/1 mice, Lewis rats
    • Adjuvant-induced arthritis: rats
  • Lung Disease
    • Asthma
    • Acute lung injury models
  • Inflammatory Bowel Disease
  •  repeated Autoimmunity/Inflammation
    • EAE model: SJL mouse, Lewis rats
    • Lupus: NZBxNZW F1 mouse, MRL/LPR
  •  not part of inflammationOther
    • Delayed-type hypersensitivity in mice
    • Anaphylaxis model in mice
    • Endotoxemia models in mice and rats
    • Peritonitis in mice and rats
    •  captured above under dermal inflammationCitrobacter-induced colitis in mice
    • AOM/DSS model of colitis associated cancer