The Aragen preformulation team is experienced in developing technologies to support efficacy, PK and toxicology studies in different species. With strong expertise in solid form optimization and formulation development, we select appropriate solid forms and recommend preclinical formulations. Our preformulation, biology, chemistry and DMPK teams collaborate to provide integrated solutions. We use relevant scientific data to predict and assess developability of new chemical entities (NCEs) with minimal quantities of drug substance, to achieve faster to clinic milestones.

Preformulation Solutions

  • Compound profiling: solid state, solubility and stability
  • Crystallization development
  • Single crystal development
  • Co-crystal selection
  • Polymorph selection
  • Salt selection
  • Efficacy and PK formulation development