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The preformulation team supports efficacy, PK and toxicology studies through solid-form optimisation, formulation development and preclinical formulation recommendations. With strong expertise in solid form optimization and formulation development, we select appropriate solid forms and recommend preclinical formulations. Our preformulation, biology, chemistry and DMPK teams collaborate to provide integrated solutions. We use relevant scientific data to predict and assess developability of new chemical entities (NCEs) with minimal quantities of drug substance, to support developability assessment and preclinical development planning.

Preformulation Solutions

  • Compound profiling: solid state, solubility and stability
  • Crystallization development
  • Single crystal development
  • Co-crystal selection
  • Polymorph selection
  • Salt selection
  • Efficacy and PK formulation development