GET IN TOUCH

Specialty
Chemistry

Extensive institutional knowledge in diverse synthetic technologies enables us to build differentiating chemistry platforms. Aragen’s specialty chemistry teams synthesize highly complex molecules with structure characterization and corroboration, using advanced analytical tools.

Carbohydrates

A dedicated group handles carbohydrates such as oligosaccharide building blocks, complex oligosaccharides (up to octamers), glycophosphatidylinositol (GPI), glycosylated amino acids and glycoconjugates, providing novel targets for drug development programs.

Nucleosides/ Nucleotides

Our team enables diverse and complex nucleoside/nucleotide chemistry, with demonstrated expertise in the creation of phosphoramidate prodrugs using ProTide technology.

  • Complex ribo-, aza-, carba- and C- nucleosides with natural and unnatural nucleic bases
  • Proficiency in the synthesis of mono-, di- and triphosphates, and nucleoside conjugates
  • Extensive analytical infrastructure and experience in the purification of small libraries of nucleotides and ProTide phosphorus diastereomer separation

Boron Chemistry

Aragen scientists are experienced in the application of organoboron reagents to enable chemical transformations.

  • Stereoselective or racemic synthesis of α-aminoboronic derivatives and their chiral purification
  • Preparation of diverse alicyclic, aryl and heteroaryl oxaboroles
  • Synthesis of organoboron reagents: aryl/heteroaryl boronates, boronic acids and trifluoroborates for Suzuki-Miyaura coupling
  • Hydroboration and borane mediated reductions

Protein Degraders

Leveraging our scientific experience in design and synthesis, we provide valuable proteolytic molecules for preclinical and lead optimization requirements.

  • Extensive experience in design and synthesis of novel warheads ligands, hetero-bifunctional E3 ligase ligands (VHL, CRBN, IAP), linkers (alkyls, ethers, PEG) and ‘Pre-PROTAC’ tool kits for libraries
  • State-of-the-art analytical infrastructure and purification set up to deliver achiral or chiral PROTAC molecules rapidly, to multigram scale

Lipids

We offer expertise in synthesis of chromophoric and non-chromophoric lipids to address any potential permeability challenges in the implementation of delivery tools for precision medicine.

  • Acyclic and cyclic long chain fatty acids, PEGylates, dendrimers with >2,000 Da
  • Support small to large scale requirements
  • Strong analytical tools and stationary phases for purification and characterization

Deuterium Chemistry

We have developed vast experience in the synthesis of deuterated compounds in various reaction types, to understand reaction kinetics and mechanism, drug metabolism, improve PK profiles and the structural elucidation of macromolecules.

  • Reaction capabilities: mg to g scale
  • Reaction types: reduction, metal/D exchange on any substrate, deuterated AAs, etc.
  • Quantification of deuterated molecules with analytical tools

Learn more about our end-to-end capabilities