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Publications

2019

Chemistry

Galeterone and the Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-resistant Prostate Cancer Preclinical Models in vitro and in vivo

Andrew K. Kwegyir-Afful, Senthilmurugan Ramalingam, Vidya P. Ramamurthy, Puranik Purushottamachar, Francis N. Murigi, Tadas S. Vasaitis, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Sudhir Tiwari, Pratima Srivastava, Ivo P. Nnane, Arif Hussain, Yun Qiu, David J. Weber, Vincent C. O. Njar
(Basel). 2019 Nov; 11(11), 1637

Chemistry

Oxidative Degradation Profile Studies of Tavaborole by a Validated Stability Indicating RP-UPLC method: Isolation and Characterization of Novel Degradant using 2D-NMR and HRMS

Umamaheshwar Puppala , Vishnu Murthy Marisetti, Koduri S V Srinivas, K Venkateshwara Reddy, Muralidharan Kaliyaperumal, Raju Doddipalla
Biomedical Chromatography | Language: English, Database: CAplus and MEDLINE

Chemistry

Biology

Mass Spectrometry as a Workhorse for Preclinical Drug Discovery: Special Emphasis on Drug Metabolism and Pharmacokinetics

Vijayabhaskar Veeravalli, Lakshmi Mohan Vamsi Madgula, Pratima Srivastava
10.5772/intechopen.88385. In book: Mass Spectrometry – Future Perceptions and Applications

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Publications

2019

Galeterone and the Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-resistant Prostate Cancer Preclinical Models in vitro and in vivo

Oxidative Degradation Profile Studies of Tavaborole by a Validated Stability Indicating RP-UPLC method: Isolation and Characterization of Novel Degradant using 2D-NMR and HRMS

Mass Spectrometry as a Workhorse for Preclinical Drug Discovery: Special Emphasis on Drug Metabolism and Pharmacokinetics

Investigation of the Inhibition of Eight Major Human Cytochrome P450 Isozymes by a Probe Substrate Cocktail In Vitro with Emphasis on CYP2E1

Oral Pharmacokinetics of Sildenafil in the Presence of CYP3A4-Inducer and -Inhibitor using Cannulated and Non-Cannulated Male Swiss Albino Mice

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation In Drug Discovery and Development

2018

Design, Synthesis and Anticancer Evaluation of Spiro[Cyclohexane-1,1’-Indene]-2,5-Diene Analogues

An Efficient Method for the Preparation of N -Formamides using Propylphosphonic Anhydride (T3P)

An Efficient Microwave-Assisted Propylphosphonic Anhydride (T3P®)-Mediated One-Pot Chromone Synthesis via Enaminones

An Efficient One-Pot Green Approach for the Synthesis of A-aminonitriles with Alsba-15 as Nano Tubular Catalytic Reactor

The Disappearing Director: The Case of Directed N-Arylation via a Removable Hydroxyl Group

Highly Efficient Metal-Free One-Pot Synthesis of α- aminophosphonates through Reduction followed by Kabachnik–Fields Reaction Using Three-Component System

First Total Synthesis of Medicinally Important 3,4,7-Trimethoxy-9, 10-Dihydrophenanthrene-1,5-Diol

Preclinical Pharmacokinetics, Antitumor Activity and Single Ascending Dose Tolerability of GBO-006 Nanosuspension, A Selective Polo-Like Kinase 2 (PLK2) Inhibitor

2017

"One-Pot" Selective Synthesis of 3,4-Disubstituted Pyrroles and Benzo[F]Indole-4,9-Diones from 1,3-Indanedione, Aromatic Aldehydes and Tosmic

Synthesis of Novel Fused Chromone–Pyrimidine Hybrids and 2,4,5-Trisubstituted Pyrimidine Derivatives via ANRORC Rearrangement

A Novel Synthesis of Chromone Based Unnatural α-Amino Acid Derivatives

One-Pot Synthesis of 7-chloro-2-arylthieno[3,2-b]pyridin-3-ols and their Derivatization to the Corresponding Arylamino, Arylthio, and Aryloxy

Pd-PEPPSI-Ipentcl: A New Highly Efficient Ligand-Free and Recyclable Catalyst System for the Synthesis Of 2-Substituted Indoles via Domino Copper-Free Sonogashira Coupling/Cyclization

First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine

Synthesis of Spiroindene-1,3-Dione Isothiazolines via a Cascade Michael/1,3-Dipolar Cycloaddition Reaction of 1,3,4-Oxathiazol-2-one and 2-Arylidene-1,3-Indandiones

Cytochrome P450 Enzymes, Drug Transporters and their Role in Pharmacokinetic Drug-Drug Interactions of Xenobiotics: A Comprehensive Review

Characterization of 1-Aminobenzotriazole and Ketoconazole as Novel Inhibitors of Monoamine Oxidase (MAO): An In Vitro Investigation

2016

Drug Metabolism – Metabolite Identification Using Advance LC-MS/MS System

Design, Synthesis and Biological Evaluation of Diaziridinyl Quinone Isoxazole Hybrids

Design and Synthesis of Diaziridinyl Quinone Thiadiazole Hybrids via Nitrile Sulfide Cycloaddition Reaction as a Key Step

An Efficient Method for the Preparation of N-Formyl-Imide via Amidine using Propylphosphonic Anhydride (T3P®)

I2–DMSO Promoted Metal Free Oxidative Cyclization for the Synthesis of Substituted Indoles and Pyrroles

A New Metabolite of Paricalcitol: Stereoselective Synthesis of (22Z)-Isomer of 1a, 25-Dihydroxy-19-Norvitamin D2

An Efficient Synthesis of 8-Substituted Odoratine Derivatives by the Suzuki Coupling Reaction

Preclinical Formulation for the Pharmacokinetics and Efficacy of GBO-006, a Selective Polo Like Kinase 2 (PLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer

Design, Synthesis, and Evaluation of (2S, 4R)-Ketoconazole Sulfonamide Analogs as Potential Treatments for Metabolic Syndrome

Synthesis of 6-Oxopyrimidin-1(6H)-Yl Benzamide Derivatives and Evaluation of their Antibacterial and Cytotoxic Activity

Design, Synthesis and Biological Evaluation of Diaziridinyl Quinone Isoxazole Hybrids

2015

Synthesis of New Kojic Acid Based Unnatural α-Amino Acid Derivatives.

Pd Catalyzed C–N Bond Forming Reactions of 6-Bromo-2-Cyclopropyl-3-(Pyridyl-3-ylmethyl)-4-quinazolin-(3H)-one at Room Temperature

Facile and Short Synthesis of (+) 1-Hydroxy Indolizidine and (+) Coniceine from Picolinic Acid Ethyl Ester via Cross Claisen Condensation

Synthesis, In Vitro Anticancer And Antimycobacterial Evaluation of new 5-(2,5-dimethoxyphenyl)-1,3,4-thiadiazole-2-amino Derivatives

Mild and General Access to Diverse 1H-Benzotriazoles via Diboron-Mediated N–OH Deoxygenation, and Pd-Catalyzed C–C and C–N Bond Formation

Design, Synthesis, And Biological Evaluation Of Quinazoline Derivatives As α-glucosidase Inhibitors

Breaking the Sensitivity Limitations of Cytochrome P450 Oxidation Product: Dansyl Chloride Derivatization Of 4-OH Mephenytoin, a CYP2C19 Metabolite and its Application to In Vitro CYP Inhibition Assay

Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitative Estimation of Solutol HS15 and its Applications

Development and Application of PI3K Assays for Novel Drug Discovery

2014

Novel Imidazoline Antimicrobial Scaffold That Inhibits DNA Replication with Activity against Mycobacteria and Drug Resistant Gram-Positive Cocci

Design, Synthesis and Biological Evaluation of Novel Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitors

Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids

First Total synthesis of (-)-Auranomide C and its Derivatives

Synthesis, Anticonvulsant, Sedative and Anxiolytic Activities of Novel Annulated Pyrrolo[1,4]benzodiazepines

A Convenient and Efficient Synthesis of 2-(Het)arylthieno[3,2-b]pyridine-7(4H)-ones and 2,3-Di(het)arylthieno[3,2-b]pyridine-7(4H)-ones

Pyrrolidine and Piperidine Based Chiral Spiro and Fused Scaffolds via Build/Couple/Pair Approach

Effect of Milnacipran and Atorvastatin Alone and in Combination in Rodent Model of Inflammatory Pain

Optimization of Bupivacaine Induced Subarachnoid Block by Clonidine: Effect of Different Doses of Oral Clonidine

A Randomized Double-Blinded Dose Response Study of the Fentanyl with Hyperbaric Ropivacaine in Caesarean Section

Atorvastatin Potentiates the Anti-Nociceptive Effect of Milnacipran in Carrageenan-Induced Inflammatory Pain Model in Rats

Development of Phosphocellulose Paper-Based Screening of Inhibitors of Lipid Kinases: Case Study with PI3K?

ATP Competition of PI3K Inhibitors using Phosphocellulose Paper Approach

Liquid Chromatography/Tandem Mass Spectrometry Method for Estimation of Cholic Acid in Rat Plasma, Urine and its Application

2013

Identification and Reduction of Matrix Effects caused by Cremophor EL In Bioanalysis using Liquid Chromatography/Tandem Mass Spectrometry

Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitative Estimation of Polyethyleneglycol 400 and its Applications

Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis

Facile Total Synthesis Of Gymnoconjugatin A and B

A Reagent Based DOS Strategy via Evans Chiral Auxiliary: Highly Stereoselective Michael Reaction Towards Optically Active Quinolizidinones, Piperidinones And Pyrrolidinones

Diversity Oriented Synthesis of Macrocyclic Diaryl Ethers by Dötz Benzannulation

A Novel One-Pot Synthesis of 7-methoxy-2-arylthieno – [3,2-b] pyridine-3-ols in Domino Fashion

Concise Total Synthesis of (-)-Erinapyrone B from D-(+)-Malic Acid

Development of α-Glucosidase Inhibitors by Room Temperature C–C Cross Couplings of Quinazolinones

Ethyl-1-Imidazole Carbamate (EImC) as a Carbonylating Agent: Efficient Synthesis of Oxazolidin-2-ones from Amino Alcohols

Identification and Reduction of Matrix Effects caused by Solutol HS15 in Bioanalysis using Liquid Chromatography/Tandem Mass Spectrometry

Liquid Chromatography/Tandem Mass Spectrophotometry Method for Quantitation of Cremophor EL and its Applications

Bioanalytical Method Development and Validation for Estimation of Duloxetine Hydrochloride in Human Plasma using LC-MS/MS

Determination of Cremophor EL in Rat Plasma by LC-MS/MS: Application to a Pharmacokinetic Study