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Brochure

Intox Safety Assessment

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Industries we serve

  • Pharma/ Biotech
  • Medical Devices
  • Plant Protection
  • Industrial Chemicals
  • Nutraceuticals

Regulatory Compliances

Test systems and routes of administration
Test Species
  • Rats, mice, guinea pigs, rabbits, hamsters
  • Dogs and Non-Human Primates, available through our
    collaborating test facilities
Routes of Administration
  • Oral (gavage & dietary), dermal, inhalation, parenteral (IV/SC/IM/ID)
  • Other – Intranasal, ocular, intra-vitreal, otic, intra-articular;
  • Implantation
Bioanalytical / Bioassay Solutions
  • Single/Repeated Dose Pharmacokinetics
  • Toxicokinetics
  • Immunogenicity (ADA)
  • Immunotoxicology
  • Biomarkers
  • Acute Phase Proteins
  • Biodistribution/Persistence
Bioanalytical Techniques
  • LC–MS (liquid chromatography–mass spectrometry)
  • GC–MS (gas chromatography–mass spectrometry)
  • HPLC (high performance liquid chromatography)
  • Ligand binding assay (LBA) Platforms- ELISA and Meso Scale
    Discovery (MSD)
Studies offered
Mutagenicity:
  • In-vitro / in-vivo studies
  • Gene mutation – Bacterial (Ames test); mammalian cells
  • Chromosome Aberration; Micronucleus Test
Acute Toxicity:
  • Acute oral, dermal, inhalation toxicity;
  • Acute dermal & eye irritation/ corrosion; Mucous membrane irritation;
  • Skin sensitization – Buehler, GPMT, LLNA
Subchronic / Chronic Toxicity / Carcinogenicity
  • 7-day (DRF), 14-day, 28-day, 90-day, 180-day and
    12-month repeat dose studies
  • 18-month/24-month carcinogenicity bioassays
  • Implantation studies on medical devices
Reproductive Toxicity
  • Fertility, Developmental toxicity, One/Multi-generation
    studies