Peptide Capabilities at ARAGEN
Innovating Complexity. Scaling Precision. Empowering Discovery.
At Aragen, with over 10 years of dedicated experience, we specialize in comprehensive peptide synthesis services, helping innovators move peptide-based therapeutics from concept to preclinical scale. Our team of 80 peptide scientists and 40 analytical experts based in Hyderabad work across all phases of peptide synthesis program development—from design and synthesis to purification, modification, and large-scale non-GMP production.
Our cutting-edge infrastructure and deep scientific expertise allow us to tackle challenging sequences, deliver high-quality peptides at varied scales, and support our customers in advancing their programs confidently and efficiently with our reliable custom peptide solutions.
Comprehensive Peptide Synthesis
At Aragen, we provide versatile peptide synthesis solutions using an extensive range of chemistries, empowering you to develop peptides customized for any research or therapeutic application. Our capabilities include:
Whether your goal is stable peptides for drug discovery, diagnostic conjugates, or long peptides for structural studies, our expertise and infrastructure enable efficient design and synthesis to meet your specific needs. We also integrate conformationally constrained THF amino acids into solid-phase peptide synthesis (SPPS) to improve peptide stability and bioactivity.
Our custom peptide projects benefit from tailored workflows, ensuring that each sequence’s unique properties are optimized throughout the peptide synthesis process.
Advanced Modifications & Cyclization
We offer a broad spectrum of peptide modifications and cyclization strategies to maximize peptide stability, bioactivity, and target engagement.
C-Terminal Modifications
N-Terminal & Side-Chain Functionalization
Cyclization Strategies
Peptide Solutions for Every Application
At Aragen, we specialize in synthesizing a diverse portfolio of peptide classes, each engineered for specific therapeutic and diagnostic applications. Our expertise ensures you have access to the exact peptide tools required to investigate novel targets, explore unique mechanisms of action, and optimize delivery strategies for your research and development goals.
| Peptide Type | Features & Applications |
|---|---|
| Cyclic Peptides | Increased enzymatic stability and receptor affinity, ideal for drug discovery and peptide vaccines |
| Disulfide-Bridged Peptides | Structural stability and mimicking protein loops for targeting intracellular proteins and receptors |
| Stapled Peptides | Enhanced α-helicity, protease resistance, and cell penetration for intracellular targeting |
| Bi-cyclic Peptides | High binding specificity and metabolic stability for use in diagnostics, imaging, and therapeutics |
| Boronic Acid Peptides | Reversible binding to diols for sensing applications, proteasome inhibition, and controlled delivery |
| Glycopeptides | Carbohydrate-modified peptides for immune modulation, receptor selectivity, and diagnostic purposes; synthesized using advanced linkers like 4-(hydroxymethyl)phenol |
| DOTA-Derivatized Peptides | Radiolabeling-ready scaffolds for imaging and targeted therapy |
| Fluorescent/Tagged Peptides | Chromophore and fluorophore additions for visualization, molecular tracking, and real-time imaging; successfully conjugated at >1 g scale with >97% purity |
| Synthetic Protein Fragments | Long peptides (>150 AAs) synthesized via NCL/KAHA for structure-function studies and drug targets |
Infrastructure for Synthesis & Scale-Up
Our state-of-the-art peptide synthesis platforms and scale-up capabilities enable us to support projects from early-stage discovery to large-scale production.
Automated Synthesis Platforms
Scale Range
Our scalable systems, from small-scale R&D to larger preclinical supply, minimize the risk of technology transfer and provide flexibility across stages of discovery and development. Whether you’re progressing from the lab to IND-enabling studies or moving toward commercialization, we can help facilitate each stage with reliable output and consistency in our custom peptide synthesis service.
Analytical & Purification Capabilities
Ensuring the purity and identity of your peptides is paramount, and our advanced analytical techniques and purification infrastructure are designed to meet those needs.
Analytical Techniques
Infrastructure & Columns
Purification Range
With these resources available with us, you gain rapid method development, consistent quality control, and the confidence that your peptides meet the highest standards of purity—essential for advancing your projects toward clinical testing.
Resins & Reagents
We utilize a broad array of resins and coupling reagents to ensure optimized peptide synthesis. The right resin and reagent choice significantly impacts yield, purity, and functionalization.
Resins In Routine Use
Coupling Reagents
The strategic selection of resins and reagents tailored for your specific peptide sequences ensures the optimization of synthesis, leading to higher purity, more efficient yields, and reliable outcomes even for complex, challenging peptides.
Why Aragen?
At Aragen, we deliver the scientific expertise, advanced infrastructure, and adaptability you need to advance your peptide-based therapeutics from discovery through clinical development.
By choosing Aragen, you gain a trusted partner with the technical depth and scalable solutions to ensure your peptides consistently meet the highest standards—from early research to clinical testing.
Let’s Advance Your Peptide Pipeline
From challenging sequences to scalable supply, Aragen is ready to support your success with precision chemistry, deep collaboration, and cutting-edge capabilities. Reach out today to discuss how we can support your next peptide program.
Ensuring the quality, reliability and data accuracy of synthesized compounds, prior to biological testing in the drug discovery process.
20+ years experience in executing parallel processing and focused analytics to mitigate risks to client programs and shorten the timeline to IND, with scalable and reproducible processes.
Earning the complete trust and confidence of our customers.
