Rodent pharmacokinetics (in life) vivarium studies are conducted in-house on different strains of mice and rats, in accordance with the following certifications, compliances and quality systems:
Ninety SOPs have been established for the regular functioning of the vivarium and for the various studies being conducted.
In-house, experienced scientists conduct cannulations, ensuring minimal stress to the animals, with cost-effectiveness. Sampling can be done through portal/ tail/ saphenous/ submandibular veins. Wherever possible, we employ the principle of 3Rs. Serial sampling is preferred, to reduce the number of animals and generate quality, robust data.
Large Animals: Canine PK studies are conducted with an external collaborator having a colony of more than 400 animals at a time.
|Study Type||TAT (Days)||Compound Requirement (mg)|
|Mouse PK: serial sampling||5||10|
|Mouse PK: parallel sampling||5||20|
|Rat Blood Brain Barrier||5||15|
|Mouse Blood Brain Barrier||5||15|
|Cassette dosing||5||25 in rats|