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Comprehensive Solutions for Animal Health Biologics

Cell Line Development

Gene to GMP Solutions
200+ cell lines, 3 commercially used
Cell line development for canine, feline mAbs and fusion proteins
Familiarity with USDA and CVB requirements
Royalty-free CHO-DG44 and CHO-GS and CHO-GS FUT∞KO Platforms
8 g/L titers with assured product quality

Protein Sciences

Expertise in the production of canine, feline, equine, porcine and bovine antibodies/proteins
Experience with diverse formats including IgG, BsAbs, scFv, IgM and chimeric mAbs

Analytics

Ag-Ab binding affinity
Enzyme activity
Cell-based assays
Isothermal stability
HPLC, ELISA, A280
SEC-MALS
CE-SDS and more

Process Development &
Characterization

Fully automated Ambr® 250 Bioreactors
Multifactorial DOE
Upstream PD for higher titers and shorter timelines
Robust scalable upstream development

GMP Manufacturing

Single-use bioreactors 50L, 200L, 500L, and 2,000L with total expansion capacity to 23,000L
High productivity with minimum titers of 4 g/L for most mAbs and BsAbs; scaling up to 25
g/L after process intensification
DS Production Ready and DP Underway