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Home Small Molecules Discovery (CRO) Integrated Drug Discovery IDD Overview

IDD Overview

Aragen’s Integrated Drug Discovery platform combines in-house discovery capabilities, data science and structural biology/crystallography within a coordinated programme model

Integrated drug discovery icon: three interlocking gears containing analytics, target and cost-saving symbols
Efficiency icon: stopwatch with motion lines
Efficiency

In-house Drug Discovery Capabilities
Concept to Proof-of-Concept

Cost savings icon: money bag with dollar sign
Savings

Structural Biology, Crystallography and Library Screening*
With our strategic PROTEROS and Nanoimaging partnership

Accuracy icon: target with an arrow in the bullseye
Accuracy

Computational Biology
& Data Science

Target identification icon: DNA helix under a magnifying glassTarget Identification & validation

  • Clear link of MOA to disease model
  • Target based Due Diligence; using genetic or pharmacological toolsTarget based Due Diligence; using genetic or pharmacological tools

Protein structure icon: folded protein outlineHit ID

  • Identify compound (s) that modify function or activity of target
  • Structural Biology, crystallography

Network icon: person surrounded by a ring of nodesLead Identification

  • Identify one or more chemical series with acceptable preliminary DMPK, safety and potency profile

In vivo icon: mouse with a syringeLead Optimization

  • Optimize compounds for DMPK, safety, physiochemical properties
  • Establish in vivo efficacy in appropriate models
Checklist icon: clipboard with ticked itemsDevelopment candidate profiling
  • Demonstrate critical physiochemical, DMPK, safety and preclinical efficacy attributes

Checklist icon: clipboard with ticked itemsIND Enabling Studies

  • Complete GLP toxicology and safety pharmacology studies, drug substance process, scale up, clinical formulation, clinical supplies manufacture and release and submission package

What we bring:

  • Work in close collaboration with our drug discovery / development partners
  • To develop research strategies and workflows to advance programs from concept to clinic / commercial
  • To de-risk approaches by seeking timely actionable data
  • To provide project management support that enables coordinated and efficient programme execution

We have implemented digital platform InCoRe for Design-Make-Test-Analyze’ (DMTA) cycle and compound data management system (CDMS) for effective project management.

CDMS is designed to have an integrated digital process platform from compound registration to assay results and data storage for analysis. IDD’s partners can directly monitor the projects in real time and make compound assay requests directly from partner’s location.

This platform is an integration of digital tools as well as customised automated platforms for data acquisition, data transfer and data analysis. It is the integrated discovery workflow for CADD-Medchem-Biology-DMPK that ensures easy tracking, smooth data transfer and clear visualization across the various project stake holders.