One of the key challenges in leading a successful hit identification (HI) campaign is to obtain a novel molecule with a confirmed structure and reproducible activity in a relevant bioassay. Additionally, target specificity and chemical tractability can pave the way for a strong Hit-to-Lead and further all the way to IND nomination.
IDD’s medicinal chemistry teams have the knowledge and experience to support hit generation, confirmation and prioritisation within integrated discovery programmes. We employ a multi-pronged approach in generating hits with concomitant data generation. Integration of these data against agreed hit-evaluation criteria supports hit confirmation and lead-series prioritisation.
Selecting a programme-appropriate hit-identification strategy
IDD teams employ multiple hit identification techniques in engaging with our partners as they aim to discovery a novel hit series.
Team typically work with a set of Hit selection criteria agreed with the partner at program initiation. A typical Hit selection criteria set includes setting the cut-offs on the following parameters :
