GET IN TOUCH

In-vitro assay Development (biochemical/ cell-based)

In-vitro Biology: Models & Platforms for Assays

Within our Integrated Drug Discovery portfolio, Aragen’s in vitro biology models and platforms support drug discovery research across a range of therapeutic areas. Our assay capabilities are organised across four primary verticals to address specific research requirements.

Our platform technologies include a range of assay types spanning biochemical and cell-based assays to support the evaluation of drug interactions and mechanisms of action. Target Class specialization allows us to tailor assays to intricate molecular targets, offering nuanced perspectives crucial for therapeutic breakthroughs. Our proficiency spans an extensive range of Therapeutic Areas, enabling us to customize assays tailored to the unique challenges of each therapeutic landscape. Furthermore, our expansive models cater to diverse disease contexts, spanning Oncology, Inflammation, Infectious Diseases, Respiratory Diseases, Metabolic Disorders, and more. This comprehensive integration of models and platforms underscores our commitment to delivering pioneering solutions at the forefront of drug discovery.

In-vitro Biology: HTS Capabilities

High Throughput Screening (HTS) stands as the cornerstone of our Integrated Drug Discovery capabilities. Our HTS platform supports systematic screening of compound libraries to identify and prioritise compounds for further evaluation.

We offer versatile throughput screening solutions, facilitating the examination of compounds against a diverse array of targets encompassing various therapeutic areas. Our flexible Assay Formats cater to different screening needs, whether biochemical, cellular, or functional assays, ensuring a tailored approach for each project. Seamless Data Transfer processes enable swift and secure handling of screening data, optimizing efficiency. Assay Readouts encompass a range of sophisticated methods, providing comprehensive insights into compound interactions, allowing us to streamline the drug discovery journey towards transformative outcomes.

In-vitro Biology: Protein Production Capabilities

  • Protein production and characterisation workflows support assay reagent generation
  • Membrane proteins such as VLPS, especially GPCRs & other receptors
  • High-throughput expression screening and optimization in 96-well format
  • Low endotoxin protein purification
  • Characterization and validation of the proteins by SEC, Western, ELISA, BIAcore, FACS, IEF, 2D
  • Functional validation of protein produced by various assay platforms

Protein Production Capacities and Timelines

In vitro Biology

  • Protein and cell line generation
  • Screening Platforms – HTS
  • Electrophysiology
  • Disease models – Oncology, Pain, Inflammation, Fibrosis etc.
  • Histopathology & Clinical pathology