Protein Degraders and Modulators
Protein degraders, including PROTACs and molecular glues, are being investigated as approaches to modulate disease-relevant proteins through cellular degradation pathways. These approaches:
- Enable targeted protein degradation by recruiting E3 ligases to unwanted proteins, facilitating their elimination.
- Provide an alternative to traditional inhibition, allowing dynamic modulation of protein levels rather than permanent binding.
- Target elusive proteins, such as transcription factors or scaffolding proteins, previously considered “undruggable.”
Our capabilities include rational design, synthesis and screening workflows for selected degrader/modulator programmes.
